IndraLab

Statements

reach
"Since TREK channels are activated by PIP 2 it is possible that the DCPIB effect is mediated via an allosteric enhancement of the PIP 2 effect rather than a direct competition with it."
26837888
reach
"As mentioned, PIP 2 could also indirectly activate TREK-1 through the enzyme PLD2."
28793254
reach
"Unexpectedly, sub-saturating PIP 2 (0.5 mol%) in the presence of 10 mol% PG enhanced TREK-1 activity (XREF_FIG and XREF_FIG)."
28793254
reach
"PIP 2 can also indirectly activate TREK-1 through PIP 2 agonism of PLD2 [XREF_BIBR], making PIP 2 regulation complicated [XREF_BIBR]."
30529033
reach
"In contrast with PG and PA, increasing concentrations of PIP 2 (0.5, 1, and 2 mol%) failed to activate TREK-1 : the highest concentration of PIP 2, 2 mol%, induced the least flux (XREF_FIG and XREF_FIG)."
28793254
reach
"These findings combined with Comoglio 's model of localization of PLD2 in the activation of TREK-1 suggest PIP 2 could indirectly activate TREK-1 through increasing PLD2 activation and production of PA and PG agonists (see XREF_SUPPLEMENTARY)."
28793254