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Bortezomib inhibits NFKB1. 18 / 21
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"They showed that proteasome inhibitor bortezomib more effectively inhibited nuclear localization of RELA and p50 than cREL or alternate pathway subunits NF-kappaB2 or RELB in tumor specimens and lines from patients with HNSCC."
18694378
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"After treatment, bortezomib had up-regulated DIABLO and NFkBIB (NF-kB inhibitor), and down-regulated the NF-kB1, NF-kB2, and BIRC1, an anti-apoptotic gene (XREF_FIG)."
25913414
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"There is also evidence that lapatinib induces constitutive activation of NF-kB rendering the tumor cells more vulnerable to NF-KB inhibition by bortezomib."
31538230
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"In further support of NFkB 's critical role in HL, the stimulation of CD30 and concomitant inhibition of NFkB by bortezomib, a proteosome inhibitor, induced enhanced anti-tumor effects in both in vitro and in vivo HL models [89]."
21619423
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"Besides IkappaBalpha and p65, we also observed degradation of p105 by Bortezomib in a dose- and time dependent manner."
| PMC
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"This is the first report showing degradation of p105 by Bortezomib."
| PMC
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"In addition, pathways identified in this study such as PI3K-AKT-mTOR signaling inhibited using the drugs idelalisib, AZD8835, and rapamycin; BCR and NF-KB signaling inhibited by ibrutinib and bortezomib can be combined with R-CHOP."
36831263
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"It has been described that bortezomib, by stabilizing NFKBIA (NFKB inhibitor alpha), blocks the activity of the NFKB (nuclear factor kappa B) signaling pathway, resulting in the downregulation of its anti-apoptotic target genes, increasing the sensitivity of cancer cells to chemotherapy [79]."
32401642
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"Higher doses of carfilzomib were associated with higher rates of CVAE [XREF_BIBR] Ixazomib is an oral analog of Bortezomib, reversibly inhibiting the proteasome and the NFKB pathways in myeloma supporting cells, influencing cytokines important for cell growth."
33613788
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"Furthermore, inhibition of pan-caspases abolished Bortezomib induced degradation of p65, p105 and Sp proteins, but not that of IkappaBalpha."
| PMC
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"As NFKB inhibition seems to be the primary mode of action of Ifi202b , drugs capable of promoting NFKB inactivation, such as bortezomib, should augment TNF-alpha efficacy or reproduce some of its effe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23534980
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"In CD30th cHL cell lines, the proteosome inhibitor bortezomib, which downregulates NFkB, exhibited antiproliferative effects, induced cell cycle arrest and caused apoptosis [59]."
19373650
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"Our case was resistant to the IL-6 receptor inhibitor tocilizumab, immunomodulator lenalidomide, and NFKB blocker bortezomib but had a dramatic response to sirolimus therapy."
36401154
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"They showed that inactivation of NF-k-B by Bortezomib (PS-341) or an I-k Ba inhibitor (BAY 11) is sufficient to induct cell cycle arrest and cell death both in cell lines (Mino, DB) and in primary MCL cells.The NF-k-B family consists of five members,c-rel, p65 (Rel A), Rel B, p50 and p105 (NF-k B1) and p52 / p100 (NF-k B2) [84] and presents a pool of transcription factors regulating several genes responsible for immune and inflammatory response, cell proliferation and apoptosis prevention."
16321849
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"In preclinical mesothelioma models, the proteasome inhibitor bortezomib inhibits constitutive activation of NFkB and enhances the cytotoxicity of cisplatin and pemetrexed [XREF_BIBR, XREF_BIBR]."
18770046
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"Bortezomib also effectively induced degradation of the p105 and p50 subunits of NF-kappaB in a dose dependent manner (XREF_FIG)."
| PMC
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"These studies show that bortezomib reduces blood proteasome activity by 77% and also reduces NFKB and eNOS (nitric oxide synthase) expression following harmful ischemia."
19181875
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"Bortezomib, a 26S proteasome inhibitor, causes both increased proteasome stress and decreased NFkB activity in MM cells leading to cell death in BMSCs."
35663979