IndraLab

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"In LPS treated mice, dasatinib attenuated NLRP3 inflammasome activation, c-Abl and PKCdelta activation; and sickness behavior."
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"Thus, these data suggest that ROT-induced oxidative stress triggers c-Abl activation, leading to exacerbation of LPS-mediated induction of NLRP3 inflammasomes in microglia.It was also demonstrated that primary microglia stimulated by LPS/ROT exhibited a drastic augmentation of NLRP3 in the mitochondria compared to the control, while dasatinib pretreatment inhibited NLRP3 trafficking to the mitochondria."
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