IndraLab

Statements


USP29 activates MYC. 5 / 5
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"Our previous study showed that USP29 positively regulates the MYC downstream pathway."

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"These results indicated that USP29 may promote nucleotide biosynthesis by regulating the MYC and E2F downstream pathways."

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"Knockout of USP29 depletes MYC and markedly prolongs survival of lymphoma xenografts [ 45 ]."

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"Analysis of RNA sequencing data in SK-N-BE2 cells demonstrated that USP29 promoted the gene expression of metabolic enzymes involved in nucleotide anabolism, probably by regulating MYC and E2F downstream pathways."

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"Conversely, USP37 and USP29 promote tumorigenesis by stabilizing c-Myc through deubiquitination [22, 23]."