IndraLab

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"Thus, the present study indicates that compartmentalized cAMP, rather than total cAMP in the cytoplasm, may serve as a crucial factor in acetate-mediated attenuation of the NLRP3 inflammasome, supplementing the current theory of Ca /cAMP-mediated NLRP3 inflammasome attenuation.Post translational modification has emerged as an endogenous regulatory mechanism of the inflammasome , and several investigations have reported that ubiquitination acts as a negative regulator of NLRP3 inflammasome activation in a cAMP-PKA-dependent manner ."
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"Activation of CaSR in these cells enhanced intracellular Ca levels, reduced cyclic AMP levels, and promoted the assembly of the NLRP3 inflammasome components."
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"Taken together, these results indicate that cAMP specifically suppresses NLRP3 inflammasome activation."
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"Although ligand of NLRP3 inflammasome is unclear, enhanced cAMP production inhibited the activation of the NLRP3 inflammasome through the direct regulatory role of cAMP on the NLRP3 complex [XREF_BIBR]."
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"During the cAMP induced NLRP3 inhibition, activated PKA directly phosphorylates NLRP3 at S295 and subsequently suppresses ASC oligomer formation [XREF_BIBR]."
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"Because cAMP suppresses NLRP3 inflammasome activation and binds to the NBD of NLRP3, which is the most common location of CAPS associated mutations 1, we considered the possible effect of these mutations on binding to cAMP."
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"CASR stimulation also results in reduced intracellular cAMP, which independently activates the NLRP3 inflammasome."
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"CaSR stimulation also results in reduced intracellular cAMP, which independently activates the NLRP3 inflammasome."
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"The role of cAMP in inflammasome activation remains unclear as one study has reported that cAMP can directly inhibit NLRP3, whereas another study reported that cAMP levels had no direct influence on inflammasome activation 92."
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"However , another study showed that NLRP3 is also activated by decreased cAMP concentrations , which is in striking contrast to the study by Rossol et al. ( 2012 ) where no significant influence of cAMP levels on inflammasome activation could be detected ( Lee et al ., 2012 ) ."
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"91 Likewise, as a part of the PKA signaling pathway, cyclic adenosine monophosphate (cAMP) can also directly inhibit the NLRP3 inflammasome at Ser295 of its receptor."
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"Reductions in cytoplasmic cAMP concentrations can promote activation of the NLRP3 receptor [53–55]."
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"failed to corroborate the finding that cAMP suppresses NLRP3 activation or that extracellular Ca 2+ reduces cAMP to relieve inhibition of NLRP3."
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"Mitochondrial reactive oxygen species (ROS) generation, calcium influx, and reduction of cellular cyclic AMP (cAMP) have been reported to activate the NLRP3 inflammasome XREF_BIBR, 172, XREF_BIBR, though their effect (s) have been disputed 18."
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"Inhibition of the NLRP3 inflammasome by cAMP."
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"Forskolin, a PKA activator that increases cytoplasmic cAMP levels inhibits NLRP3 inflammasome activation by phosphorylation of the S295 residue in NLRP3."
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"While the increase of cAMP suppresses the NLRP3 inflammasome 22, it conversely potentiates pyrin inflammasome activation."
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"It was previously demonstrated that cAMP inhibits NLRP3 inflammasome through direct interaction with NLRP3 protein in mouse BMDM and in human PBMCs."
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"Mitochondrial reactive oxygen species (ROS) generation, calcium influx, and reduction of cellular cyclic AMP (cAMP) have been reported to activate the NLRP3 inflammasome XREF_BIBR, 172, XREF_BIBR, though their effect (s) have been disputed 18."
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"Increase of intracellular cAMP by an activator of adenylate cyclase or an analog of cAMP, or a blockade of cAMP degradation by phosphodiesterase inhibitor decreased NLRP3 activation."
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"To further confirm cAMP mediated NLRP3 inflammasome inhibition, we used 8-Bromo-cAMP, a cell permeable analog of cAMP."
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"Additionally, another report shows that cAMP negatively regulates the NLRP3 activation and that selected disease associated mutations have less sensitivity for cAMP regulation, which also could explain the constitutive activity XREF_BIBR."
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"Recently, cAMP has been proposed to negatively regulate NLRP3 inflammasome activation (Lee et al., 2012), so we examined the role of cAMP in DA induced inflammasome inhibition."
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"The NLRP3 inflammasome is inhibited by cAMP, and activated by ROS and ceramides [XREF_BIBR, XREF_BIBR]."
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"Finally, we examined suppressive role of cyclic AMP (cAMP) on the IL-1beta secretion from patients ' PBMCs because cAMP has been shown to suppress NLRP3 inflammasome activation (XREF_SUPPLEMENTARY)."
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"Reductions in cytoplasmic cAMP concentrations can promote activation of the NLRP3 receptor [53] [54] [55] ."
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"A decrease in cytosolic cAMP or an increase in intracellular calcium concentrations triggers the activation of the NLRP3 inflammasome."
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"Recent studies suggest that nitric oxide (NO), Ca 2+ and cyclic AMP negatively regulate the NLRP3 inflammasome but the detailed mechanisms are unclear XREF_BIBR, XREF_BIBR."
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"We found that the increase of the cAMP levels with adenylate cyclase (ADCY) activator forskolin inhibited NLRP3 inflammasome activation with a dose dependent manner, consistent with a previous report [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"NLRP3 inflammasome activation was increased with ADCY inhibitors and reduced by activators of ADCY and inhibitors of cAMP degradation."
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"To understand how cAMP might suppress NLRP3 inflammasome activation, we tested whether cAMP interacts directly with NLRP3."
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