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3',5'-cyclic AMP inhibits NLRP3. 58 / 58
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"NLRP3 inflammasome activation was increased with ADCY inhibitors and reduced by activators of ADCY and inhibitors of cAMP degradation."
25879282
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"These findings contradict published observations that IFNβ, cAMP, and more specifically PKA signaling, negatively regulates the NLRP3 inflammasome and downstream processing of pro-IL-1β to the active form."
37023458
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"failed to corroborate the finding that cAMP suppresses NLRP3 activation or that extracellular Ca 2+ reduces cAMP to relieve inhibition of NLRP3."
25879282
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"We also demonstrated that both Epac1 and PKA regulate Nek7 protein, establishing that the cAMP pathway blocks Nek7/NLRP3 signaling."
35006270
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"Increase of intracellular cAMP by an activator of adenylate cyclase or an analog of cAMP, or a blockade of cAMP degradation by phosphodiesterase inhibitor decreased NLRP3 activation."
25917098
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"Meanwhile, accumulation of cAMP would directly block the activation of NLRP3 inflammasomes."
26871480
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"The elevated intracellular cAMP levels can induce the phosphorylation and the ubiquitination of NLRP3 to block NLRP3-dependent inflammation and NLRP3-related metabolic disorders."
36899929
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"These results indicated that Salmeterol specifically suppressed NLRP3 inflammasome in BMDM among the different types of inflammasomes.In the classic GPCR signal pathway, activation of β2AR normally up[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29447945
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"We demonstrate that Genistein dose-dependently elevated intracellular cAMP level both in THP-Ms cells and U937-Ms cells, suggesting that Genistein could boost intracellular cAMP level in macrophages a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30901677
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"The participation of the E3 ligase membrane-associated ring finger (C3HC4) 7 (MARCH7) was required for the cAMP-mediated process of degrading NLRP3."
39001241
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"Inhibition of the NLRP3 inflammasome by cAMP."
27508077
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"Since cAMP has been proved to negatively regulate NLRP3 inflammasome [ 34 ], we decided to investigate potent inhibitory effect of P2Y 14 R antagonists on MSU-induced inflammatory response in THP-1 ce[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31376563
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"RAPGEF3, but not PKA, is required for cAMP-mediated NLRP3 inflammasome inhibition in endothelial cells (35)."
31131320
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"Taken together, these results indicate that cAMP specifically suppresses NLRP3 inflammasome activation."
23143333
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"Activation of CaSR in these cells enhanced intracellular Ca levels, reduced cyclic AMP levels, and promoted the assembly of the NLRP3 inflammasome components."
31547340
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"To understand how cAMP might suppress NLRP3 inflammasome activation, we tested whether cAMP interacts directly with NLRP3."
23143333
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"Because cAMP suppresses NLRP3 inflammasome activation and binds to the NBD of NLRP3, which is the most common location of CAPS associated mutations 1, we considered the possible effect of these mutations on binding to cAMP."
23143333
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"Thus, the present study indicates that compartmentalized cAMP, rather than total cAMP in the cytoplasm, may serve as a crucial factor in acetate-mediated attenuation of the NLRP3 inflammasome, supplementing the current theory of Ca /cAMP-mediated NLRP3 inflammasome attenuation.Post translational modification has emerged as an endogenous regulatory mechanism of the inflammasome , and several investigations have reported that ubiquitination acts as a negative regulator of NLRP3 inflammasome activation in a cAMP-PKA-dependent manner ."
31337751
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"It was previously demonstrated that cAMP inhibits NLRP3 inflammasome through direct interaction with NLRP3 protein in mouse BMDM and in human PBMCs."
25917098
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"Additionally, another report shows that cAMP negatively regulates the NLRP3 activation and that selected disease associated mutations have less sensitivity for cAMP regulation, which also could explain the constitutive activity XREF_BIBR."
25625584
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"Indeed, high levels of cAMP have been shown to inhibit NLRP3 by at least two mechanisms: (i) through NLRP3 ubiquitination and subsequent degradation of the protein ( Yan et al., 2015 ), and (ii) throu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29466702
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"Furthermore, the cAMP–PKA directly inhibits the rapid activation of NLRP3 inflammasome, whereas CAPS-associated mutations disable this signaling pathway [66]."
37370025
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"Others have suggested that cAMP promotes NLRP3 degradation at late time points ( Yan et al., 2015 )."
27760332
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"While the increase of cAMP suppresses the NLRP3 inflammasome 22, it conversely potentiates pyrin inflammasome activation."
27270401
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"Finally, we examined suppressive role of cyclic AMP (cAMP) on the IL-1beta secretion from patients ' PBMCs because cAMP has been shown to suppress NLRP3 inflammasome activation (XREF_SUPPLEMENTARY)."
25418813
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"However, in contrast to Lee’s work that indicates CaSR can also weaken the cAMP-dependent inhibition of NLRP3 through the inhibition of ADCY and subsequent reduction of intracellular cAMP levels, Ross[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30054020
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"Similarly, while Jae Jin Chae and colleagues proposed that cyclic AMP (cAMP) binds and inhibits NLRP3, and that Ca 2+ ‐CASR stimulation reduces cellular cAMP to promote NLRP3 activity [26] , the group[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23994495
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"Although ligand of NLRP3 inflammasome is unclear, enhanced cAMP production inhibited the activation of the NLRP3 inflammasome through the direct regulatory role of cAMP on the NLRP3 complex [XREF_BIBR]."
27143817
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"A decrease in cytosolic cAMP or an increase in intracellular calcium concentrations triggers the activation of the NLRP3 inflammasome."
24840700
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"To further confirm cAMP mediated NLRP3 inflammasome inhibition, we used 8-Bromo-cAMP, a cell permeable analog of cAMP."
25917098
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"As mentioned already repeatedly, the P2Y 14 R, initiates a signal transduction pathway via a Gi/o coupled protein to inhibit AC-mediated cAMP production that enables the activation of the NLRP3 inflam[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37423482
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"These findings suggested that dopamine enhanced viability of AML cells through DR1/5 receptor pathway.The DR1 signaling pathway was shown to inhibit the NLRP3 inflammasome stimulated by LPS and Nigeri[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34509315
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"Mitochondrial reactive oxygen species (ROS) generation, calcium influx, and reduction of cellular cyclic AMP (cAMP) have been reported to activate the NLRP3 inflammasome XREF_BIBR, 172, XREF_BIBR, though their effect (s) have been disputed 18."
26642356
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"Recent studies suggest that nitric oxide (NO), Ca 2+ and cyclic AMP negatively regulate the NLRP3 inflammasome but the detailed mechanisms are unclear XREF_BIBR, XREF_BIBR."
27439607
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"TGR5 has been reported to trigger the cAMP-dependent pathway involved in bile acid-induced NLRP3 inflammasome inhibition43, reducing macrophage inflammation and lipid loading16 and regulating nuclear factor-κB P65 activation in Crohn's disease19."
35256947
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"CaSR stimulation also results in reduced intracellular cAMP, which independently activates the NLRP3 inflammasome."
| PMC
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"Mitochondrial reactive oxygen species (ROS) generation, calcium influx, and reduction of cellular cyclic AMP (cAMP) have been reported to activate the NLRP3 inflammasome XREF_BIBR, 172, XREF_BIBR, though their effect (s) have been disputed 18."
26642356
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"Reductions in cytoplasmic cAMP concentrations can promote activation of the NLRP3 receptor [53–55]."
34059091
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"These studies have proven cAMP reverses NLRP3 inflammasome via confining its assembly."
40200750
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"91 Likewise, as a part of the PKA signaling pathway, cyclic adenosine monophosphate (cAMP) can also directly inhibit the NLRP3 inflammasome at Ser295 of its receptor."
31469975
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"Furthermore, the activation of cAMP/PKA cascade inhibited the activation of NLRP3 inflammasome ( Guo et al. 2016 )."
37353053
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"The NLRP3 inflammasome is inhibited by cAMP, and activated by ROS and ceramides [XREF_BIBR, XREF_BIBR]."
29497784
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"Forskolin, a PKA activator that increases cytoplasmic cAMP levels inhibits NLRP3 inflammasome activation by phosphorylation of the S295 residue in NLRP3."
29868015
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"Additionally, CaSR stimulation results in decreased cellular cAMP concentration, which independently activates the NLRP3 inflammasome."
29409699
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"CASR stimulation also results in reduced intracellular cAMP, which independently activates the NLRP3 inflammasome."
23143333
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"The role of cAMP in inflammasome activation remains unclear as one study has reported that cAMP can directly inhibit NLRP3, whereas another study reported that cAMP levels had no direct influence on inflammasome activation 92."
23702978
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"In recent years, several studies have confirmed that activation of the intracellular cAMP/PKA pathway can inhibit the activation of NLRP3 inflammasome and alleviate cell pyroptosis."
38820434
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"Hong et al. [52] found that ER stress can promote the activation of the cAMP/PKA pathway in type II alveolar epithelial cells, and the activation of the cAMP/PKA pathway can inhibit the activation of NLRP3 inflammasome induced by ER stress."
38820434
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"A large number of studies have confirmed that activation of cAMP/PKA can inhibit the activation of NLRP3 inflammasome [53–56]."
38820434
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"During the cAMP induced NLRP3 inhibition, activated PKA directly phosphorylates NLRP3 at S295 and subsequently suppresses ASC oligomer formation [XREF_BIBR]."
33627128
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"However , another study showed that NLRP3 is also activated by decreased cAMP concentrations , which is in striking contrast to the study by Rossol et al. ( 2012 ) where no significant influence of cAMP levels on inflammasome activation could be detected ( Lee et al ., 2012 ) ."
31191301
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"Dopamine D receptor (DRD1)-cyclic adenosine monophosphate (cAMP) signaling pathway negatively regulates NLRP3 inflammasome in both primary microglia and astrocytes."
27808010
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"DA, via the type-1 DA receptor-1 (DRD1) and cyclic AMP signaling inhibits the NLRP3 inflammasome (Yan et al., 2015)."
34656967
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"These studies establish that cAMP proteins can inhibit Nek7 and block activation of the NLRP3 inflammasome proteins."
35006270
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"Increased intracellular cAMP levels can cause PKA phosphorylation, as well as NLRP3 phosphorylation and ubiquitination, which inhibits NLRP3-dependent inflammation and NLRP3-related metabolic disorder[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36878280
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"In vitro, caffeine inhibits phosphodiestereases and thereby increases the availability of cyclic AMP, which is known to repress the NLRP3 inflammasome ( Lee et al., 2012 )."
28228276
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"Recently, cAMP has been proposed to negatively regulate NLRP3 inflammasome activation (Lee et al., 2012), so we examined the role of cAMP in DA induced inflammasome inhibition."
25594175
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"We found that the increase of the cAMP levels with adenylate cyclase (ADCY) activator forskolin inhibited NLRP3 inflammasome activation with a dose dependent manner, consistent with a previous report [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25594175