IndraLab

Statements

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"Silencing of USP3 suppressed GC cell proliferation and spreading in vitro as well as xenograft proliferation and metastasis in vivo; however, opposite results were obtained when USP3 was overexpressed."
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"Overexpression of USP3 significantly increased OS cell proliferation, migration, and invasion."
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"USP3 promotes proliferation of non small cell lung cancer through regulating RBM4."
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"Therefore, USP3 might accelerate the proliferation of NSCLC cells via regulating RBM4."
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"USP3 promotes the proliferation, migration and invasion of OS cells."
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"However, it is unknown whether these three proteins are involved in the USP3-directed proliferation of GC cells, and future studies should examine their oncogenic roles in GC."
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"USP3 knockdown inhibited the proliferation of breast cancer cells, while ectopic expression of KLF5 partially rescued this inhibitory effect (78)."
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"In contrast, overexpression of USP3 promoted cell proliferation, migration, and invasion."
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"Here, we report that ubiquitin specific peptidase 3 (USP3) promotes proliferation and metastasis of esophageal squamous cell carcinoma (ESCC) cells by mediating deubiquitination of Aurora A. Analysis of human clinical samples indicated that USP3 and Aurora A are highly expressed in ESCC."
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"Cellular experiments confirmed that high expression of USP3 and Aurora A in ESCC cells promoted malignant cell proliferation and invasion."
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"Clone formation assays ( Fig. 4 G-I) showed that upregulation of USP3 restored proliferation and Transwell assays ( Fig. 4 J-L) showed that miR-224-5p downregulation restored proliferation migration i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It promotes cell proliferation, invasion, migration, DNA damage repair, and glycolysis, potentially via the Wnt/β-catenin signaling pathway.14 Similarly, USP3 promotes cholangiocarcinoma proliferation and invasion through the Wnt/MYC pathway, enhancing tumor cell glycolysis, energy production, and upregulating metabolic target genes such as GLUT1, HK2, PDM2, and LDHA.87 Egfr/Stat3."
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"Functional phenotype analysis demonstrated that the overexpression of USP3 significantly promoted the proliferation, migration, and invasion of OS cells."
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"In vivo deletion of USP3, a deubiquitinating enzyme involved in DNA damage repair, increases the incidence of spontaneous cancer and impairs the proliferation and repopulation ability of HSCs."
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"USP3 promotes proliferation and survival of prostate cancer cells."
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"The upregulation of USP3 in GC has been found to significantly enhance cell proliferation in vitro and promote metastasis in vivo [36, 37]."
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"Additionally, we demonstrated that USP3 promoted the proliferation, migration and invasion of OS cells."
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"USP3 knockdown reduced the proliferation of PC3 and DU145 cells determined by colony formation (Fig. 2C) and EdU assays (Fig. 2D, E), and also decreased the migration of both cells by wound-healing assay (Fig. 2F, G)."
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"In addition, USP3 knockdown also reduced proliferation in non-prostate cancer cells, suggesting that USP3 may be essential to proliferation in many cell lines (Supplementary Fig. S2A–D)."
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"49 Their findings indicate that USP3 overexpression accelerates GC cell proliferation by promoting G1–S transition and upregulating cyclins D and E."
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"52 Overall, USP3 primarily functions as a tumor promoter in GC, driving GC cell proliferation, invasion, migration, and the EMT process.Ubiquitin‐specific protease 3 has also been implicated in esophageal squamous cell carcinoma (ESCC)."
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"Overexpression of USP3 significantly increased OS cell proliferation, migration, and invasion ."
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"These results underscore the key role of DNM1L in a USP3-induced enhancement of proliferation, migration, and invasion capacities of GBC cells."
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"USP3 knockdown inhibit proliferation and survival of prostate cancer cells in vitro and in vivo."
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"USP3 knockdown inhibits breast cancer cell proliferation in vitro and tumorigenesis in vivo, which can be partially rescued by ectopic expression of KLF5."
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"Elevated USP3 levels contribute to increased NSCLC cell proliferation."
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"And study revealed that USP3 promotes the proliferation and metastasis of esophageal squamous cell carcinoma by stabilizing Aurora A [41]."
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"Taken together, these data suggest that USP3 knockdown reduced long-term proliferation and survival of prostate cancer cells in vitro and in vivo."
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"Therefore, the development of an effective inhibitor with this target is expected to become an important method for the treatment of OS.In conclusion, USP3 promotes the proliferation and metastasis of OS."
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"Nagy et al. reported that USP3 promotes neuroblastoma cell viability, proliferation, and xenograft tumor growth by cleaving K48‐ and K63‐linked ubiquitin chains of MYCN (Figure 2C, right)."
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"USP3 has recently been shown to promote cell proliferation by targeting RBM4 (RNA binding motif 4) [43] or KLF5 (Krüppel-like factor 5) [44] in non-small cell lung and breast cancer cells, respectivel[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Functional studies further demonstrated that USP3 promotes osteosarcoma cell proliferation and tumor growth both in vitro and in vivo."
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"Protein deubiquitylase USP3 stabilizes Aurora A to promote proliferation and metastasis of esophageal squamous cell carcinoma."
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"Additionally, overexpressed USP3 significantly promoted cell proliferation in vitro and tumor growth in vivo, while the silencing of USP3 inhibited proliferation and tumor growth."
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