IndraLab

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MiR-30b inhibits SCN3A. 5 / 5
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"Our results showed that miR-30b agomir transfection down-regulated Nav1.3 mRNA stimulated with TNF-alpha in primary DRG neurons."
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"Through Luciferase assay we verified that miR-30b negatively regulated SCN3A by combining with SCN3A 3′UTR (Figure 1B)."
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"These results confirm that miR-30b overexpression reverses the upward tendency of Nav1.3 in SNL rats at the level of mRNA and protein, leading to a partial easement of pain."
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"Our results showed that miR-30b agomir transfection down-regulated Nav1.3 mRNA stimulated with TNF-α in primary DRG neurons."
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"However, miR-30b overexpression, by transfecting miR-30b agomir, reversed the up-regulation of SCN3A (Figure 2B, P = 0.042) and Nav1.3 (Figure 2C, P = 0.0162) and attenuated the down-regulation of miR-30b (Figure 2A, P < 0.0001)."
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