IndraLab

Statements

reach
"Intracellular K+ is required for the inactivation induced high-affinity binding of cisapride to HERG channels."
15967876
reach
"The adverse events surrounding the Phase I trials with TGN1412 led to the discovery of unexpected mechanisms related to CD28 activation in much the same way as the channelopathy, or long QT syndrome ([MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23954708
reach
"Thus, mutating these residues resulted in weak and loss of binding of cisapride to hERG, which led to poor inhibition of current in the mutant hERG systems."
33004839