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USP28 increases the amount of CDKN1A. 2 / 2
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"Furthermore, USP28 depletion reduced levels of basal and nutlin-3a-induced p21 expression (Fig. 2F), suggesting that USP28 may also affect p21 levels during replicative senescence, likely through p53."
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"Consistent with the lower expression of p53, p21 and p16, USP28-depleted 2BS cells had less blue-colored cells ( Fig. 6 C), and the numbers of senescence-positive cells in USP28 knockdown cells were a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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