IndraLab

Statements

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"Overall, UCH-L1 activates the CSC-like properties in DU145 cells through the PI3 K/Akt pathway, whereas UCH-L3 has opposite effects.As the relapse of CRPC is attributed to CSCs, we examined the relationship between the disease-free survival and the level of UCH-L1 and UCH-L3 in prostate cancer patients."
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"The CSC-like characteristics, such as the expression of pluripotency markers, chemoresistance, and sphere-forming ability, were promoted by UCH-L1, whereas those were repressed by UCH-L3."
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"The CSC-like properties were enhanced by UCH-L1 but inhibited by UCH-L3."
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"Either UCH-L1 overexpression or UCH-L3 depletion in RWPE1 cells augmented the CSC-like properties, including the induction of the pluripotent marker genes and the increase in sphere formation and drug resistance."
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"UCH-L1 increased the CSC-like properties, whereas UCH-L3 had an opposite action in prostate cancer cells."
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"In summary, UCH-L1 promotes CSC-like behaviors, and UCH-L3 has opposite effects."
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