IndraLab

Statements

CTNNB1 binds LEF1 and PITX2. 14 / 14
| 14
sparser
"LEF-1 and β-catenin bind Pitx2 promoter sequences in ocular neural crest, indicating a likely direct effect of canonical Wnt signaling on Pitx2 expression."
20960542
sparser
"The canonical Wnt signaling pathway is one mechanism where β-catenin and Lef-1 can independently interact with PITX2 to increase its transcriptional activity ( xref , xref )."
18045789
sparser
"LEF-1 and beta-catenin interactions with PITX2 provide new mechanisms for the regulation of PITX2 transcriptional activity."
15728254
sparser
"Because PITX2 interacts with β-catenin and Lef-1 to regulate gene expression we asked if Dact2 interacted with PITX2 to modulate PITX2 transcriptional activity."
23349981
sparser
"This regulation of gene expression appears to be linked with Wnt/β-catenin signaling through β-catenin interactions with Lef-1 and Pitx2."
23349981
sparser
"It was previously shown that Dact2 inhibits Lef-1 interaction with β-catenin, however, Dact2 does not appear to inhibit the interaction of Pitx2 with β-catenin or Lef-1, but modulates their synergistic transcriptional activities."
23349981
sparser
"Lef-1 and beta-catenin interact simultaneously and independently with PITX2 through two different sites to regulate PITX2 transcriptional activity."
17785445
sparser
"Our research revealed a novel interaction between PITX2, Lef-1, and beta-catenin in which the Lef-1 beta-catenin binding domain is dispensable for its interaction with PITX2."
17785445
sparser
"Furthermore, beta-catenin in combination with PITX2 synergistically activates the LEF-1 promoter and this activation is independent of the Wnt-responsive element. beta-catenin directly interacts with PITX2 to synergistically regulate LEF-1 expression."
15728254
sparser
"Β-catenin and LEF1 bind Pitx2 promoter sequences in developing periocular mesenchyme."
20960542
sparser
"Expression of Lef1 is regulated through direct physical interactions of PITX2, LEF1 and β-catenin ( xref ), and PITX2 enhances endogenous expression of the full-length β-catenin-dependent Lef1 isoform while decreasing expression of the N-terminally truncated β-catenin-independent isoform ( xref )."
20200414
sparser
"In this report, we present evidence that canonical Wnt/ β-catenin signaling is not required for initial activation of Pitx2 , but it is required for maintenance of its continued expression likely via direct binding of Lef-1 and β-catenin to the Pitx2 promoter."
20960542
sparser
"Pitx2, Lef-1 and β-catenin are associated as a complex when activating downstream gene expression xref ."
23349981
sparser
"We show a new mechanism where LEF-1 expression is regulated through PITX2, LEF-1 and beta-catenin direct physical interactions."
15728254