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NAMPT activates INSR. 45 / 50
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"Visfatin binds to and activates the insulin receptor via a distinct binding site from insulin, which stimulates glucose uptake in adipocytes [8] ."
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"Visfatin has been shown to regulate glycometabolism and activate IR, IRS, and downstream signalling proteins, all of which are linked to tumourigenesis [28–34] ."
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"Visfatin exerts insulin-mimetic effects via binding and activating the insulin receptor."
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"Visfatin is able to bind to and activate the insulin receptor on specific loci to simulate an insulin-like effect to decrease blood sugar levels ."
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"Visfatin exerts insulin-mimetic effects via binding and activating the insulin receptor [XREF_BIBR]."
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"Visfatin is related to glucose metabolism because it can bind to and activate the insulin receptor [XREF_BIBR]."
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"Visfatin binds and activates the insulin receptor causing a significant drop in glucose release from hepatocytes and stimulating glucose consumption in adipocytes[ xref ]."
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"Since e NAMPT can bind to and activate the insulin receptor, its expression level in plasma is positively correlated with obesity 19 ."
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"As regards adipokines, AGT (angiotensin) is produced constitutively and released into the circulation mainly by the liver; it increases the synthesis of LEP (leptin) that plays a key role in regulatin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Visfatin can activate IR ( Fig. 3 ), PI3K/Akt and MAPK/ERK1/2 signalling pathways ( Fig. 4 )."
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"However, it is still unclear whether or not visfatin directly acts on IR or through what mechanism visfatin activates IR."
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"Another study reported that visfatin directly binds and activates the insulin receptor to induce the phosphorylation of signal transduction proteins [ xref ]."
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"Visfatin mimics insulin by binding and activating the insulin receptor, and lowering plasma glucose; and it has been suggested that it is involved in the pathogenesis of obesity and insulin resistance[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"1 One fundamental question about the activation of the insulin receptor by visfatin is how the binding action of visfatin is transduced to intracellular autophosphorylation."
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"Visfatin directly stimulates the insulin receptor; however, the binding site is different from insulin [102]."
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"Visfatin synthesized by visceral fat activates the insulin receptor, causing an effect similar to that of insulin (an orectic action)."
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"Visfatin enhances insulin responsiveness by activating the insulin receptor, producing insulin-mimetic effects, and thereby lowers blood glucose [88]."
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"Although earlier studies demonstrated that visfatin binds to and activates insulin receptor [1] , we could not find any inhibition of visfatin-induced relaxation by a specific insulin receptor inhibit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Mechanically, visfatin activates insulin receptor (IR) and insulin receptor substrate (IRS)1/2 of EC cells to enhance their proliferation and inhibit apoptosis through PI3K/Akt and MAPK/ERK signaling pathways [52]."
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"Both visfatin and NMN induced activation of insulin receptor and extracellular signal regulated kinase (ERK) 1/2, with visfatin induced activation of insulin receptor and ERK1/2 being inhibited by FK866."
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"No visfatin receptor has yet been identified, but it was suggested that visfatin may bind and activate the insulin receptor (for review see Grolla et al. xref )."
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"Visfatin is an adipocytokine known to possess insulin-mimetic properties , functions to activate insulin receptors , and acts as a determinant of insulin resistance in obesity [ 49 ] ."
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"Visfatin in myocytes binds and activates the insulin receptor, which causes an effect that only mimics the action of insulin, as confirmed by studies showing the lack of involvement of insulin signalling pathways in the activity of visfatin [ xref ]."
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"The activation of the insulin receptor by visfatin was found in pancreatic β-cells ( Brown et al., 2010 ), as well as in osteoblasts ( Xie et al., 2007 ) and in mesangial cells of the kidneys ( Song e[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Some of these, such as visfatin can activate the insulin receptor and has insulin-like activity, but adiponectin has insulin-sensitizing effect [ xref ]."
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"On the other hand, it is suggested that visfatin can bind and activate insulin receptor (INSR), and downstream signaling pathways xref ."
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"Blood levels of visfatin increase in obesity and the cytokine can bind to and Stimulate the insulin receptor (Fukuhara et al. 2005) ."
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"Visfatin is able to bind to and activate the insulin receptor on specific loci to simulate an insulin like effect to decrease blood sugar levels."
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"Interestingly, it has been recently proposed that visfatin and Nampt can induce prostaglandin E (2) (PGE (2)) synthesis in chondrocytes by both Nampt activity and insulin receptor activation [XREF_BIBR]."
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"Mechanically, visfatin activates insulin receptor (IR) and insulin receptor substrate (IRS)1/2 of EC cells to enhance their proliferation and inhibit apoptosis through PI3K/Akt and MAPK/ERK signaling pathways [ xref ]."
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"Visfatin may activate the insulin receptor (INSR) by binding at a site other than insulin (INS) and thus act in target cells including pancreatic cells xref , osteoblasts xref , and renal mesangial cells xref ."
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"Taking all the available data together, it seems that visfatin activates the insulin receptor signalling cascade but in a manner distinct from insulin."
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"Hence, we investigated the possible activation of INSR by visfatin and its impact on the phosphorylation of several protein kinases, and whether they could mediate the action of visfatin in porcine luteal cells."
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"Visfatin may activate the insulin receptor (INSR) by binding at a site other than insulin (INS) and thus act in target cells including pancreatic cells , osteoblasts , and renal mesangial cells ."
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"By activating insulin receptor, visfatin increases glucose uptake in myocytes and preadipocytes and decreases glucose release from hepatocytes [8]."
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"As regards adipokines, AGT (angiotensin) is produced constitutively and released into the circulation mainly by the liver; it increases the synthesis of LEP (leptin) that plays a key role in regulatin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, to share the ambiguity of the other adipocytokines in their metabolic and immune functions, visfatin was found to bind to and activate the insulin receptor, but insulin does not interact with its cytokine inducing effects XREF_BIBR."
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"Our findings are consistent with those of previous studies which have demonstrated that visfatin can modulate the activation of the INSR, ERK1/2, AKT, and AMPKα signaling pathways in porcine anterior pituitary cells [63]."
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"An argument could be made that Nampt stimulated insulin receptor activity may be due, in part, to the generation of NMN in these experiments."
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"Hence, we investigated the possible activation of INSR by visfatin and its impact on the phosphorylation of several protein kinases, and whether they could mediate the action of visfatin in porcine luteal cells.Prior to our study, researchers had found that visfatin activates the MAPK/ERK1/2 pathway in the ovary; in bovine Gc, it visfatin increased phosphorylation of MAPK3/1 , while in hen Gc it reduced phosphorylation of MAPK3/1 ."
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"In human osteoblasts and mouse pancreatic beta cells , visfatin stimulated INSR as well as insulin receptor substrate 1 and 2 (IRS-1 and IRS-2, respectively)."
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"For example, in rat aorta rings, visfatin antagonizes noradrenaline-induced contraction and induces endothelium-dependent relaxation by stimulating eNOS activity via phosphorylation at Ser and de-phosphorylation of Thr , independently of insulin receptor activation [251]."
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"Although the subject of controversy, evidence exists that visfatin, encoded by NAMPT, promotes insulin secretion and insulin receptor signaling in pancreatic beta cells (Brown et al., 2010)."
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"Visfatin activates the insulin receptor and ERK1/2 signaling, thus improving glucose uptake in adipocytes and myocytes [XREF_BIBR]."
| PMC
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"Since it was previously reported that visfatin binds to and activates insulin receptor [1] , we examined the possible involvement of insulin receptor for the visfatin-induced relaxation."
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