IndraLab

Statements

NAMPT activates INSR. 17 / 22
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"However, to share the ambiguity of the other adipocytokines in their metabolic and immune functions, visfatin was found to bind to and activate the insulin receptor, but insulin does not interact with its cytokine inducing effects XREF_BIBR."
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"Visfatin is able to bind to and activate the insulin receptor on specific loci to simulate an insulin like effect to decrease blood sugar levels."
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"Some of these, such as visfatin can activate the insulin receptor and has insulin-like activity, but adiponectin has insulin-sensitizing effect [ xref ]."
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"Visfatin is able to bind to and activate the insulin receptor on specific loci to simulate an insulin-like effect to decrease blood sugar levels ."
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"Visfatin mimics insulin by binding and activating the insulin receptor, and lowering plasma glucose; and it has been suggested that it is involved in the pathogenesis of obesity and insulin resistance[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Visfatin exerts insulin-mimetic effects via binding and activating the insulin receptor [XREF_BIBR]."
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"Visfatin activates the insulin receptor and ERK1/2 signaling, thus improving glucose uptake in adipocytes and myocytes [XREF_BIBR]."
| PMC
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"Visfatin is an adipocytokine known to possess insulin-mimetic properties , functions to activate insulin receptors , and acts as a determinant of insulin resistance in obesity [ 49 ] ."
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"On the other hand, it is suggested that visfatin can bind and activate insulin receptor (INSR), and downstream signaling pathways xref ."
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"Interestingly, it has been recently proposed that visfatin and Nampt can induce prostaglandin E (2) (PGE (2)) synthesis in chondrocytes by both Nampt activity and insulin receptor activation [XREF_BIBR]."
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"An argument could be made that Nampt stimulated insulin receptor activity may be due, in part, to the generation of NMN in these experiments."
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"Visfatin enhances insulin responsiveness by activating the insulin receptor, producing insulin-mimetic effects, and thereby lowers blood glucose [88]."
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"Another study reported that visfatin directly binds and activates the insulin receptor to induce the phosphorylation of signal transduction proteins [ xref ]."
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"Visfatin is related to glucose metabolism because it can bind to and activate the insulin receptor [XREF_BIBR]."
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"Blood levels of visfatin increase in obesity and the cytokine can bind to and Stimulate the insulin receptor (Fukuhara et al. 2005) ."
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"Visfatin exerts insulin-mimetic effects via binding and activating the insulin receptor."
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"Both visfatin and NMN induced activation of insulin receptor and extracellular signal regulated kinase (ERK) 1/2, with visfatin induced activation of insulin receptor and ERK1/2 being inhibited by FK866."
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