IndraLab

Statements

ATXN3 decreases the amount of PRKN. 2 / 2
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"Polyglutamine expansion in ataxin-3 was recently shown to cause a decrease in parkin levels in a mouse model of SCA3, although the mechanism causing this decrease is unknown."
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"Furthermore, the polyglutamine expansion of ataxin-3 was recently shown to reduce parkin levels via autophagy in vivo, suggesting that ataxin-3 is another binding partner for parkin."
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