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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

ATXN3 decreases the amount of PRKN. 2 / 2

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"Polyglutamine expansion in ataxin-3 was recently shown to cause a decrease in parkin levels in a mouse model of SCA3, although the mechanism causing this decrease is unknown."

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"Furthermore, the polyglutamine expansion of ataxin-3 was recently shown to reduce parkin levels via autophagy in vivo, suggesting that ataxin-3 is another binding partner for parkin."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...