IndraLab

Statements

Mutated BAP1 activates Mesothelioma. 7 / 7
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"High frequency of germline mutations of BAP1 were demonstrated to cause mesothelioma in 2001, when an epidemic spread of cases was reported in a village in Cappadocia (113, 118)."
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"Germline BAP1 mutations cause mesothelioma and other malignancies, namely, uveal cancer, meningioma, and melanoma, overall defined as “BAP1- related cancer syndrome”."
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"Whereas BAP1 mutations drive BAP1 tumour predisposition syndrome, mesotheliomas, melanomas and other neoplasms 8–11 ; ASXL1 mutations are particularly prevalent in myeloid cancers, and are associated [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"BAP1 mutations cause prevalently mesothelioma and melanomas."
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"BAP1 mutations can lead to mesothelioma in situ in multiple serosal cavities."
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"Mutation of the BAP1 gene is known to induce diffuse malignant mesothelioma [29]."
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"The identification of BAP1 mutations in MPM has led to investigate the role of histone deacetylase inhibitors in mesothelioma patients.The phase III trial on 661 pretreated patients randomly assigned [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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