IndraLab

Statements

ATXN3 activates HTT. 5 / 6
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"The decrease in NPY level leads to the development of anxiety, depression, AUD, SUD, Alzheimer’s, multiple sclerosis, schizophrenia, and MJD, whereas an increase in migraine, PD, and HD."
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"Expression of mHTT decreased the activity of ATXN3, which negatively affected transcription and DNA repair and might trigger neurotoxicity in HD (Gao et al., 2019)."
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"The group of polyQ-associated disorders includes Huntington’s disease (HD), caused by the aggregation of the protein huntingtin , and Machado–Joseph disease (MJD) (or spinocerebellar ataxia type 3), which results from the aggregation of Ataxin-3 ."
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"In conclusion, our findings do not provide strong evidence that ataxin-3, a DUB implicated in protein quality control, modulates polyglutamine induced disease in a knock-in mouse model of HD."
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"Huntington’s disease (HD) and spinocerebellar ataxia type 3 (SCA3, also called Machado-Joseph disease) are caused by extensive polyglutamine (polyQ) expansion of the huntingtin or ataxin-3 protein [334]."
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