IndraLab

Statements

COPS6 inhibits fbxw1. 2 / 2
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"Because Cullin neddylation, a process controlled by CSN, decreases the steady-state expression levels of F-box proteins, we rationalized that CSN6 may be involved in Cullin neddylation, thereby increasing the autocatalytic degradation of beta-Trcp."
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"As expected, we found that the beta-catenin level decreased and that of beta-Trcp increased when cells were treated with CSN6-shRNA (CSN6 knockdown) (Fig XREF_FIG A and B)."
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