IndraLab

Statements

COPS6 inhibits fbxw1. 4 / 4
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"Because Cullin neddylation, a process controlled by CSN, decreases the steady-state expression levels of F-box proteins (Wee et al., 2005), we rationalized that CSN6 may be involved in Cullin neddylat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As expected, we found that the beta-catenin level decreased and that of beta-Trcp increased when cells were treated with CSN6-shRNA (CSN6 knockdown) (Fig XREF_FIG A and B)."
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"Because Cullin neddylation, a process controlled by CSN, decreases the steady-state expression levels of F-box proteins, we rationalized that CSN6 may be involved in Cullin neddylation, thereby increasing the autocatalytic degradation of beta-Trcp."
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"In the xenografted colon cancer samples, CSN6 depletion inhibited tumor growth by increasing beta-Trcp while downregulating beta-catenin."
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