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Shikonin inhibits NLRP3. 14 / 14
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"Shikonin reduces LPS-induced heart dysfunction by preventing NLRP3 inflammasomes from activating SIRT1-dependently ."
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"As a PKM2 inhibitor, Shikonin can prevent muscle cell pyroptosis by indirectly inhibiting the activation of the NLRP3 inflammasome (82, 111), potentially providing therapeutic benefits in idiopathic inflammatory myopathies.Some other NLRP3 inhibitors have been studied for other metabolic and autoimmune diseases, but have not been tested in the context of IIM."
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"In the present study we showed that shikonin inhibits NLRP3 inflammasome activation by acting on both signals."
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"Correction : Shikonin Suppresses NLRP3 and AIM2 Inflammasomes by Direct Inhibition of Caspase-1."
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"For example, Shikonin (extracted from Chinese herb radix arnebiae) ameliorated cardiac dysfunction and inhibited the activation of NLRP3 inflammasome in lipopolysaccharide (LPS)-induced cardiac dysfunction (Guo et al., 2020)."
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"We further showed that shikonin suppresses NLRP3 dependent maturation of IL-1beta induced by soluble as well as particulate triggers."
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"As shown in Fig. 3 D, NLRP3 expression was markedly induced in Akata cells exposed to anti-sIg whereas shikonin treatment reduced NLRP3 expression close to basal levels even at the lowest concentratio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Shikonin Suppresses NLRP3 and AIM2 Inflammasomes by Direct Inhibition of Caspase-1."
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"We demonstrated that shikonin at non toxic concentrations inhibits NLRP3 inflammasome activation by nigericin."
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"Based on its reported antipyretic and anti-inflammatory properties, we investigated whether shikonin suppresses the activation of NLRP3 inflammasome."
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"Shikonin decreased NLRP3 inflammasome activation in response to nigericin more potently than acetylshikonin."
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"To determine whether shikonin specifically inhibits NLRP3 inflammasome in response to nigericin or has broader action, we tested its inhibitory capacity in treatment with various NLRP3 inflammasome activators."
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"Our results demonstrate that shikonin inhibits NLRP3 inflammasome activation independently of the NLRP3 trigger used, suggesting that it acts at downstream stages of inflammasome activation."
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"As the recruitment of adaptor protein ASC and activation of caspase-1 are common to several inflammasomes including the AIM2 inflammasome, we were interested whether shikonin specifically inhibits NLRP3 inflammasome."
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