IndraLab

Statements

Shikonin inhibits NLRP3. 11 / 11
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"Shikonin decreased NLRP3 inflammasome activation in response to nigericin more potently than acetylshikonin."
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"In the present study we showed that shikonin inhibits NLRP3 inflammasome activation by acting on both signals."
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"As the recruitment of adaptor protein ASC and activation of caspase-1 are common to several inflammasomes including the AIM2 inflammasome, we were interested whether shikonin specifically inhibits NLRP3 inflammasome."
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"We demonstrated that shikonin at non toxic concentrations inhibits NLRP3 inflammasome activation by nigericin."
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"Shikonin Suppresses NLRP3 and AIM2 Inflammasomes by Direct Inhibition of Caspase-1."
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"For example, Shikonin (extracted from Chinese herb radix arnebiae) ameliorated cardiac dysfunction and inhibited the activation of NLRP3 inflammasome in lipopolysaccharide (LPS)-induced cardiac dysfunction (Guo et al., 2020)."
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"Our results demonstrate that shikonin inhibits NLRP3 inflammasome activation independently of the NLRP3 trigger used, suggesting that it acts at downstream stages of inflammasome activation."
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"To determine whether shikonin specifically inhibits NLRP3 inflammasome in response to nigericin or has broader action, we tested its inhibitory capacity in treatment with various NLRP3 inflammasome activators."
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"Based on its reported antipyretic and anti-inflammatory properties, we investigated whether shikonin suppresses the activation of NLRP3 inflammasome."
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"Correction : Shikonin Suppresses NLRP3 and AIM2 Inflammasomes by Direct Inhibition of Caspase-1."
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"We further showed that shikonin suppresses NLRP3 dependent maturation of IL-1beta induced by soluble as well as particulate triggers."
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