IndraLab

Statements

Ubiquitin activates USP5. 5 / 8
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"Both free and substrate conjugated polyubiquitin chains accumulate in leon mutants, suggesting that abnormal ubiquitin homeostasis caused tissue disorder and lethality in leon mutants."
25152394
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"Recognition of the free C-terminus of the proximal ubiquitin in a poly-ubiquitin chain has been shown to stimulate the activity of USP5."
20434206
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"It is known that occupancy of the S1 ' site by the proximal ubiquitin activates USP5 and that the C-terminal glycine (G76) of this ubiquitin is determinant for this activation XREF_BIBR XREF_BIBR."
26235645
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"Our finding suggests that the previous finding that ubiquitin (not C-terminal truncated) enhances the activity of USP5 37 is due to the binding of the beta-grasp domain of ubiquitin."
25263960
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"While submicromolar concentrations of ubiquitin activate isopeptidase T, higher concentrations are inhibitory."
7548011