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Interferon increases the amount of USP18. 13 / 15
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"Like ISG15, the expression of its conjugating enzymes and USP18 is upregulated by IFN (XREF_FIG a)."
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"Previous studies have shown that the expression of USP18 could be rapidly induced by interferon, viral infection, and genotoxic stress XREF_BIBR."
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"Forty of the 71 interferon-stimulated genes, including myxovirus resistance (Mx) 1, Mx2, 2’−5’-oligoadenylate synthase-like protein 1 (Oasl1), Rsad2, nicotinamide phosphoribosyltransferase (Nampt), interferon-stimulated gene (Isg) 15, Isg20, and ubiquitin specific peptidase 18 (Usp18), were expressed at higher levels in Mkp-1 mice than in Mkp-1 mice following E. coli infection."
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"To investigate whether endogenous IFN signaling induces USP18 expression during tumor development in vivo, we inoculated C57BL/6 mice with B16-GFP tumor cells."
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"IFNα also induced UBE1L, UBE2L6, Herc5, and USP18 expression as reported previously (Fig. 1A and B) [[10], [11], [12],[34], [35], [36]]."
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"It has been shown in hepatocytes that while both IFNβ1 and IFNα induce the expression of ubiquitin-specific peptidase 18 (USP18), only IFNα signaling was profoundly impacted by downregulation by USP18[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, USP18 expression is strongly stimulated by IFN treatment and exerts negative regulation of type I interferon signaling, which is independent of its enzymatic activity 21."
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"IFNβ dose-dependently increased the mRNA expression of the canonical ISGs Oasl2 and Usp18, peaking at 6 h and decreasing following 24 h, suggesting TI-IFN pathway activation (Figure 2A)."
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"Thus in A549 cells, ISGylation is a highly stable post-translational modification even when USP18 expression has been induced by 24 h interferon stimulation."
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"In these cells, USP18 is expressed following interferon stimulation, yet in distinction to other cell types, there is minimal induction of ISGylation, UBA7 and UBCH8."
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"ISG43 expression is induced by interferon and negatively regulated by RNase-L."
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"The expression of Mx2, Rsad2, Ifit3, Herc5 and Usp18, but not RnaseL and Ifitm3, was significantly induced by the IFN injection in the PBS control group."
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"The other tool required is a means to acutely switch off ISGylation following the accumulation of a global ISGylation signal and significant levels of USP18 following interferon stimulation."
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