IndraLab

Statements

Interferon increases the amount of USP18. 8 / 10
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"Previous studies have shown that the expression of USP18 could be rapidly induced by interferon, viral infection, and genotoxic stress XREF_BIBR."
26240016
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"To investigate whether endogenous IFN signaling induces USP18 expression during tumor development in vivo, we inoculated C57BL/6 mice with B16-GFP tumor cells."
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"However, USP18 expression is strongly stimulated by IFN treatment and exerts negative regulation of type I interferon signaling, which is independent of its enzymatic activity 21."
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"Like ISG15, the expression of its conjugating enzymes and USP18 is upregulated by IFN (Fig. 1a) ."
30890331
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"Forty of the 71 interferon-stimulated genes, including myxovirus resistance (Mx) 1, Mx2, 2’−5’-oligoadenylate synthase-like protein 1 (Oasl1), Rsad2, nicotinamide phosphoribosyltransferase (Nampt), interferon-stimulated gene (Isg) 15, Isg20, and ubiquitin specific peptidase 18 (Usp18), were expressed at higher levels in Mkp-1 mice than in Mkp-1 mice following E. coli infection."
34039638
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"ISG43 expression is induced by interferon and negatively regulated by RNase-L."
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"The expression of Mx2, Rsad2, Ifit3, Herc5 and Usp18, but not RnaseL and Ifitm3, was significantly induced by the IFN injection in the PBS control group."
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"Like ISG15, the expression of its conjugating enzymes and USP18 is upregulated by IFN (XREF_FIG a)."
30890331