IndraLab

Statements

USP8 activates LRIG1. 4 / 4
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"These results suggest that simultaneous blockage of USP8 may further enhance LRIG1 dependent Met degradation and subsequent tumor growth inhibition by SAIT301 and other Met targeting drugs that have a similar mechanism of action."
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"This result suggests that SAIT301 perturbs USP8 mediated modulation of LRIG1, resulting in the degradation of LRIG1."
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"Over-expression of USP8 substantially reduced the LRIG1 degradation (XREF_FIG)."
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"Moreover, we showed that suppression of USP8 activity, by over-expression of USP8-CS, led to enhancement of the anti-tumor activity of Met targeting therapeutic antibody by promoting degradation of both Met and LRIG1."
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