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SGK3 activates KCNH2. 4 / 6
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"Interestingly, it has been reported that the serum and glucocorticoid inducible kinase 3 (SGK3) up-regulates I hERG1 by increasing protein levels in the plasma membrane, without affecting the K + chan[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"(Figure 2)In SGK3 and potassium transport, SGK3 can participate in up-regulating the activities of Kir2.1, Kir2.2, hERG, Kv7.1, BKCa, and Na /K - ATPase or indirectly enhance the potassium current induced by KCNA5 and Kv1.3 through the phosphorylation of Nedd4-2, participating in cardiac action potential, provide power for cardiac contraction, participate in renal proximal tubular membrane potential, maintain renal proximal tubular reabsorption function, and regulate neuronal excitability (Table 2)."
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"SGK3 could up-regulate the activity and abundance of hERG and change the duration of cardiac action potential."
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"HERG channel activity is up-regulated by the serum- and glucocorticoid inducible kinase isoforms SGK1 and SGK3."
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