IndraLab

Statements

OTUD3 binds cGAS. 7 / 7
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"At the same time, the same amount of HA-OTUD3 WT and HA-OTUD3 CA were captured in corresponding pull-down samples, meaning that more FLAG-cGAS was not pulled down due to the interaction between cGAS a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To investigate whether OTUD3 interacts with cGAS, we carried out coIP from cells using FLAG-OTUD3 together with hemagglutinin (HA)-cGAS, and found HA-cGAS in FLAG-OTUD3 IP sample but not in control im[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Collectively, through its context-dependent regulation of pivotal signaling hubs—MAVS, STING, and cGAS—OTUD3 functions as a master integrator."
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"As shown in Figure 3 D, it is obvious that OTUD3 C76S associates with both MAVS and cGAS, which is different from the reported result stating that cGAS did not interact with OTUD3 C76S but MAVS did."
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"Because OTUD3 interacts with cGAS and its enzyme activity is required for regulating antiviral signaling, we investigated whether OTUD3 eliminated polyubiquitin chains from cGAS."
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"We also demonstrate that OTUD3 can bind with DNA directly, not only leading OTUD3 to the cytosolic DNA complex but also increasing the association of cGAS with OTUD3, which indicates that OTUD3 has a [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"17 Taken together, our results demonstrate that both OTUD3 WT and C76S catalytic mutant associate with cGAS."
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