IndraLab

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OTUB1 deubiquitinates RACK1. 3 / 3
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"All these data demonstrated that OTUB1 deubiquitinates RACK1 and improves its stability by inhibiting ubiquitin-proteasome pathway-mediated degradation.Then, a series of domain-deleted mutants of OTUB1 and RACK1 were constructed for further research."
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"Subsequently, we investigated if OTUB1 might deubiquitylate RACK1."
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"Meanwhile, in vitro ubiquitination assay showed OTUB1 overexpression notably reduced RACK1 ubiquitination in HEK293T cells (Fig. 5i)."
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