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USP5 inhibits Polyubiquitin. 2 / 2
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"For example, the knockdown of USP5, which allows the competitive binding of accumulated unanchored polyubiquitin, inhibits proteasomal recognition sites on P53, thereby inhibiting the proteasomal-mediated degradation of p53 and increasing its transcriptional activity to negatively regulate p53-related pathways [48] (Figure 2A)."