IndraLab

Statements

OTUB1 binds SQSTM1. 5 / 5
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"To further elucidate the underlying mechanism by which OTUB1 silencing activates autophagy during ferroptosis, we conducted IP/MS analyses and identified a direct interaction between the OTUB1 and P62 proteins in C2C12 cells."
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"In this study, we demonstrated a stable interaction between OTUB1 and P62 that eliminates P62 ubiquitination and subsequently reduces P62 degradation in C2C12 cells."
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"Furthermore, OTUB1 interacted with the P62 protein and stabilized its expression by deubiquitinating it, thereby inhibiting autophagy-dependent ferroptosis and promoting myogenesis."
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"All of these findings demonstrate the critical role that OTUB1 plays in controlling ferroptosis, and we suggest that focusing on the OTUB1-P62 axis may be a useful tactic in the treatment and prevention of disorders involving the skeletal muscle."
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"OTUB1 interacts with P62 to modulate autophagy-mediated ferroptosis."
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