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BAP1 inhibits Cholangiocarcinoma. 3 / 3

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"In addition to other factors, the deubiquitinating enzyme BAP1 is a tumor suppressor in cholangiocarcinoma."

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"BAP1 knockout in mice leads to MM growth, larger tumors and increased number of metastases and BAP1 protein expression is also correlated with poor prognosis and shorter survival in RCC and cholangiocarcinoma, as well as UM (22–25)."

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"BAP1 restricted the growth cycle of intrahepatic cholangiocarcinoma by regulating ERK1/2 and JNK/c-Jun axis (Chen et al. 2018)."

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BAP1 inhibits Cholangiocarcinoma. 3 / 3

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