IndraLab

Statements

GFRA2 binds GRN. 8 / 8
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sparser
"Moreover, we determined that PGRN can directly interact with GFRA2 [ xref ]."
33433878
reach
"Co-immunoprecipitation experiments in HEK293T cells were done to test for a direct interaction between GFRA2 and progranulin."
29724592
reach
"No effect of rs36196656 on plasma and CSF progranulin concentrations was detected by ELISA; however, co-immunoprecipitation experiments in HEK293T cells did suggest a direct binding of progranulin and GFRA2."
29724592
sparser
"Co-immunoprecipitation experiments in HEK293T cells were performed to test for a direct interaction between GFRA2 and PGRN"
29724592
sparser
"No effect of rs36196656 on plasma and cerebrospinal fluid PGRN levels was detected by ELISA; however, co-immunoprecipitation experiments in HEK cells did suggest a direct binding of PGRN and GFRA2."
29724592
sparser
"We next hypothesized that GFRA2 might directly interact with PGRN and serve as a receptor for PGRN."
29724592
sparser
"In-vitro, we obtained evidence of a direct binding of PGRN to GFRA2 which could suggest that GFRA2 may be a signaling receptor for PGRN; however, future experiments both in vitro and in vivo will be needed to determine the functional consequences of this interaction."
29724592
sparser
"Functional studies also showed that PGRN binds to GFRA2 in vitro."
29724592