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Statements

USP15 binds PLOD2. 8 / 8
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"Studies by Tong et al. revealed that in breast cancer EMT, PLOD2 is associated with increased cytoplasmic succinate, driving mesenchymal transformations and enhancing cancer cell stemness while reducing 5-hydroxymethylcytosine (5hmC) levels in chromatin upon silencing of PLOD2. xref Additionally, Lan et al. uncovered a critical interaction between PLOD2 and USP15, a deubiquitinating enzyme, that stabilizes and activates the AKT/mTOR signaling pathway, consequently fostering the progression of colorectal cancer. xref This interaction underscores the emerging complexities of PLOD2ʼs role in cancer signaling networks."
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"In addition, PLOD2 interacted with USP15 by stabilizing it in the cytoplasm and then activated the phosphorylation of AKT/mTOR, thereby promoting CRC progression."
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"PLOD2 interacts with USP15 by inhibiting protein degradation of ubiquitination in the cytoplasm."
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"PLOD2 interacted with USP15 in colorectal carcinoma cells."
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"Co‐immunoprecipitation (Co‐IP) was performed to examine the interaction between PLOD2 and USP15, and the results indicated that PLOD2 probably precipitated with USP15 (Figure  xref )."
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"48 Additionally, Lan et al. uncovered a critical interaction between PLOD2 and USP15, a deubiquitinating enzyme, that stabilizes and activates the AKT/mTOR signaling pathway, consequently fostering the progression of colorectal cancer."
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No evidence text available
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"Lan et al. demonstrated that USP15 interacts with PLOD2 via immunoprecipitation."
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