IndraLab

Statements

Apigenin inhibits CHUK. 6 / 6
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"Given the role for IKKalpha mediated NF-kB signaling in tumorigenesis and the IKKalpha activation in prostate cancer we provide in vitro experimental evidence that apigenin specifically binds with IKKalpha with higher affinity than IKKbeta and blocks IKKalpha activation, which correlated with reduced migration of cancer cells treated with apigenin."
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"Additionally , we have found that apigenin , a flavonoid with anti-cancer properties , inhibits the expression of IKKalpha and attenuates most of the pro-tumoral EMT changes induced by IKKalpha in mouse tumor keratinocytes ."
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"Apigenin blocks IKKalpha activation and suppresses prostate cancer progression."
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"Further research work is needed to investigate how apigenin mediated IKKalpha inhibition affects downstream mechanisms involved in the process of metastasis."
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"Apigenin blocks catalytic site of IKKalpha and IKKbeta-In silico molecular modeling."
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"In this study, we present several lines of evidence that IKKalpha plays an important role in cancer progression and that apigenin specifically blocks IKKalpha activation, leading to decreased proliferation and enhanced apoptosis in prostate cancer cells."
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