IndraLab

Statements

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"USP6 depletion could inhibit cell proliferation and migration, reduce the colony number and induce apoptosis, which could be reversed by GOLPH3 overexpression in HT29 and HCT116 cells ( Fig. 3 F–I)."
38735445
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"The overactive USP6 protein promotes cell survival, proliferation, and resistance to apoptosis, all of which are significant features of cancer growth."
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"USP6 also induces surface upregulation of the receptor for the apoptosis-inducing ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), providing an additional route for enhanced sensitivity to NK cell killing."
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