IndraLab

Statements

XPC binds OTUD4. 4 / 4
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"We validated the XPC-OTUD4 interaction by co-IP and demonstrated that OTUD4 knockdown in human cells indeed affects the levels of ubiquitinated XPC, supporting a hypothesis that the OTUD4 deubiquitinase is involved in XPC recycling by removing the ubiquitin moiety."
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"In addition, we have validated the OTUD4–XPC interaction in Human cells."
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"We found that XPC and OTUD4 interact directly in a co-immunoprecipitation experiment ( xref )."
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"Importantly, we validated the XPC-OTUD4 interaction by co-IP and provided evidence that OTUD4 knockdown in human cells indeed affects the levels of ubiquitinated XPC, supporting a hypothesis that the OTUD4 deubiquitinase is involved in XPC recycling by cleaving the ubiquitin moiety."
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