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MYC binds USP22. 15 / 25
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"Reciprocal co-IP assays in 293T cells demonstrated that ectopically expressed FLAG-BRD4 interacted with ectopically expressed Myc-USP22 ( Fig. 5 E and F)."
33826947
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"Indeed, USP22 interaction with FoxM1 was detected in HEK-293T cells transiently transfected Myc-USP22 and Flag-FoxM1, but not in control cells transfected with Flag-FoxM1 or Myc-USP22 alone ( xref )."
37398311
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"As shown in Fig. 5 G, the ubiquitination level of BRD4 was decreased when Myc-USP22 was co-transfected into 293T cells."
33826947
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"The data presented here suggest that the recruitment of USP22 to Myc targets as part of the hSAGA complex may provide this critical function.An outstanding question raised by these studies is the iden[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18206973
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"It has been reported that SIRT1 protein level is increased in LSCs in both chronic myeloid leukemia (CML) and acute myeloid leukemia (AML), by either transcriptional induction in CML or by c-Myc-USP22 mediated stabilization of SIRT1 protein in AML [ xref ]."
34147543
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"These unique cellular effects are mediated through USP22's interaction with c-Myc which enhances c-Myc deubiquitination and reduces intracellular glycolysis [ xref ]."
38702734
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"Western blotting analysis detected the Flag-tagged FOXO1 in anti-Myc immunoprecipitants of human embryonic kidney (HEK) 293T cells when myc-USP22 but not empty vector was cotransfected ( xref )."
39151008
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"Indeed, USP22 interaction with FoxM1 was detected in HEK-293T cells transiently transfected with Myc-USP22 and Flag-FoxM1 but not in control cells transfected with Flag-FoxM1 or Myc-USP22 alone ( xref C)."
39246448
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"USP22 interacts with MYC through its N-terminal region containing zinc finger motif and abrogates Fbw7-mediated polyubiquitination and degradation of MYC."
31832515
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"These results support a role for USP22 in MYC-mediated increase in SIRT1 protein stabilization, and indicate that FLT3-ITD, c-MYC and USP22 form an oncogenic network that enhances SIRT1 expression and activity in leukemic cells."
26049753
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"In addition, it has been shown that USP22 interacts with the c-Myc transcription factor in cancer cells ( xref ), and genetic c-Myc suppression impairs iNKT development but with increased PLZF expression ( xref ; xref ), raising the possibility that USP22 represses PLZF expression through its interaction with c-Myc."
32069354
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"However, ChIP analysis failed detect USP22 binding to PLZF promoter DNA, together with the fact that USP22 interaction with c-Myc enhances but not suppresses c-Myc transcriptional activity ( xref ), largely excluding the possibility that USP22 inhibits PLZF transcription through c-Myc."
32069354
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"The results showed an interaction between endogenous USP22 and c-Myc proteins ( Figure 5 A), which was subsequently confirmed by Co-IP assay with anti-c-Myc ( Figure 5 B)."
36528490
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"The results showed that USP22 interacted with c-Myc and increased its stabilization by deubiquitination."
36528490
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"These unique cellular effects are mediated through USP22's interaction with c-Myc which enhances c-Myc deubiquitination and reduces intracellular glycolysis [60]."
38702734