IndraLab

Statements

Calcitriol increases the amount of KCNH1. 4 / 4
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"In addition, both astemizole and calcitriol negatively targeted Eag1 gene expression, which together with the functional blockade of Eag1 channel activity by astemizole, may further explain the highly effective antiproliferative effects of the combined treatment, as reflected herein in the synergistic inhibition of cell growth and Ki-67 expression."
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"Inhibition of Eag1 mRNA expression by calcitriol was also corroborated in MDA-MB-231 cells, which further supported our observations in tumor derived cells."
19932096
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"Remarkably, the reduced expression of Kv10.1 induced by calcitriol, parallels the decrease of cell proliferation in cervical cancer cells."
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"In fact, this is the first time that inhibition of the oncogenic potassium channel Eag1 expression by calcitriol is reported."
19932096