IndraLab

Statements

USP7 inhibits immune response. 9 / 9
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"The DUB USP7 is critical for Treg maintenance since inhibition or deletion of USP7 results in decreased FoxP3 protein stability and augmented anti-tumour immunity [50,51] (Fig. S4A)."
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"USP7 targeting modulates anti-tumor immune response by reprogramming Tumor associated Macrophages in Lung Cancer."
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"USP7 can also promote the degradation of MDM2 to inhibit the p53-mediated anti-tumor immune response."
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"USP2b, USP3, USP18, USP25, UL36USP and HAUSP play a role of antivirus; while USP4, USP13, USP15 and USP17 negatively regulate antiviral immune response."
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"USP7 inhibitors likewise inhibit tumor proliferation and promote PD-1 / PD-L1 expression and immune response ( 31 ) ."
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"USP7 inhibition contributed to TAMs polarization into proinflammatory M1 macrophages and promoted the local anti-tumor immune response in TME in vivo, while also inducing systemic adaptive anti-tumor immunity."
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"USP7 inhibition promotes anti‐tumour immunity leading to synergy with immune‐checkpoint‐inhibitors, improved tumour efficacy and significant gains in survival benefit."
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"In the current study, we utilized our co-culture models of pDCs, T cells, or NK cells with autologous patient MM cells to examine whether USP7 inhibition also stimulates anti-MM immunity."
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"Pharmacological inhibition of USP7 promotes antitumor immunity and contributes to colon cancer therapy."
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