IndraLab

Statements

XL019 inhibits JAK1. 3 / 3
1 | 2
reach
"XL019 does not inhibit JAK1 (IC50 = 132 nM) or JAK3 (IC50 = 250 nM)."
22035745
reach
"Most experience has been in patients with myelofibrosis in phase I/II trials employing INCB018424 (a potent and selective inhibitor of JAK1 and JAK2), TG101348 (a structure based drug designed to inhibit JAK2 with great selectivity), CEP-701 (a multikinase inhibitor), and XL019 (a selective JAK2 inhibitor whose clinical development has been halted because of neurotoxicity)."
20948870
tas
No evidence text available
23127890