IndraLab

Statements

BRAF phosphorylated on S429 is inactive. 3 / 3
3 |
signor
"Akt phosphorylates both S364 and S428. Akt downregulates B-Raf activity in vivo"
10869359
signor
"The in vitro phosphorylation of a site unique to B-Raf (Ser429) has been proposed to be responsible for the negative regulation of the isoenzyme by Akt. Using phosphopetide mapping and site-directed mutagenesis we showed that Ser429 is phosphorylated upon cAMP elevation in PC12 cells and proposed that PKA is a major kinase phosphorylating the B-Raf-specific site in vivo"
11510412
signor
"Direct phosphorylation of B-Raf by PKA exerts a negative effect on its kinase activity, essentially via phosphorylation of Ser429"
11510412