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OTUD5 increases the amount of PDCD5. 6 / 6
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"Importantly, overexpression of wild-type OTUD5 robustly increased the levels of endogenous PDCD5, as well as p53."
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"Collectively, these results demonstrated that OTUD5 stabilized PDCD5 via dequibiquitination of PDCD5 at Lys-97 and 98.Because overexpression of OTUD5 enhanced the levels of PDCD5, we next examined whe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Overexpression of OTUD5 increased the levels of PDCD5 and p53 in a time-dependent manner; whereas knockdown of OTUD5 substantially impaired the positive effect of ET on PDCD5 and p53 activation ( Fig.[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Taken together, we concluded that OTUD5 increased PDCD5 levels via interaction with its UIM motif.Because overexpression of OTUD5 enhanced PDCD5 expression, we next examined if OTUD5 increased the sta[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Importantly, knockdown of OTUD5 reversed the effect of PDCD5 overexpression on p53 activation, indicating that OTUD5 is required for PDCD5-mediated p53 activation ( Fig. 3C )."
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"Furthermore, OTUD5 increased PDCD5 levels by mediating deubiquitination of PDCD5 at Lys-97/98."
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