IndraLab

Statements

OTULIN activates CYLD. 3 / 3
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"Interestingly , recent findings also suggest that OTULIN deficiency results in spontaneous inhibitory phosphorylation of CYLD , thereby limiting CYLD activity , which can be rescued by LUBAC inhibition [ 47 ] ."
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"In addition, OTULIN depletion inhibited CYLD activity via a Met1-Ub-dependent mechanism through phosphorylation and proteasomal degradation, resulting in excessive necroptotic RIPK1 Lys63-Ub."
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"Saleh et al. [ 79 ] also found that OTULIN depletion inhibits CYLD activity, leading to excessive necroptotic RIPK1 Lys63-Ub via a Met1-Ub-dependent mechanism."
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