IndraLab

Statements

Phosphorylated RPS6KB1 phosphorylates RPS6. 9 / 10
1 | 9
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"Both the phosphorylated p70S6K and phosphorylated rpS6 expression were reduced in the FulvC2 as compared to the parental and other sublines."
24724101
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"Activated mTOR phosphorylates p70 ribosomal protein S6 kinase (p70S6K) followed by p70S6K induced phosphorylation of ribosomal protein S6 and eukaryotic initiation factor 4B (eIF-4B) which promotes the initiation of protein translation."
22889863
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"In particular, phosphorylated p70S6K enhances phosphorylation and activity of ribosomal protein S6 and initiates various translation activities required for cell growth."
26604880
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"Increased phosphorylation of S6K1 promotes the phosphorylation of its downstream targets, RPS6 and eEF2."
| PMC
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"It is known that mTOR phosphorylates p70S6K followed by p70S6K induced phosphorylation of eIF4B and S6 (XREF_FIG)."
22889863
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"This activation subsequently enhanced the phosphorylation of the downstream target S6K1, which in turn further promoted RPS6 phosphorylation."
| PMC
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"Phosphorylation of p70S6K stimulates its phosphorylation of ribosomal protein S6, initiating a variety of translation associated activities."
24348522
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"Intriguingly, forced activation of TAK1 through overexpression of TAK1 and TAB1 does not affect the phosphorylation of mTOR or S6K1 yet induces rpS6 phosphorylation and augments protein synthesis in skeletal muscle."
36789559
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"It has been well established that activation of PI3K/Akt/mTOR pathway leads to phosphorylation of p70S6 kinase, which subsequently induces the phosphorylation of ribosomal protein S6."
19827268