IndraLab

Statements

USP28 decreases the amount of FBXW7. 3 / 3
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"Overexpressing USP28 reduced the expression of FBXW7 and suppressed FBXW7-185aa-induced c-Myc destabilization (XREF_FIG H)."
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"Complete knockdown of USP28 in mice triggers the auto-ubiquitination of FBXW7 and leads to substrate accumulation, while maintaining the single allele deletion of USP28 partially restores FBXW7 expression, and substrate protein levels are reduced in all mouse tissues [50]."
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"Knockdown of Usp28 in human tumor cells also decreased endogenous Fbw7 levels, suggesting that regulation by Usp28 is a conserved mechanism that maintains Fbw7 stability."
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