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USP28 decreases the amount of FBXW7. 2 / 2

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"Knockdown of Usp28 in human tumor cells also decreased endogenous Fbw7 levels, suggesting that regulation by Usp28 is a conserved mechanism that maintains Fbw7 stability."

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"Overexpressing USP28 reduced the expression of FBXW7 and suppressed FBXW7-185aa-induced c-Myc destabilization (XREF_FIG H)."

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IndraLab

Statements

USP28 decreases the amount of FBXW7. 2 / 2

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