IndraLab

Statements

USP9X inhibits MTOR. 5 / 5
| 4 1
reach
"USP9X, as a novel mTORC1 and -2 binding partner, negatively regulates mTOR activity and further affects the differentiation of skeletal muscle [XREF_BIBR]."
23768211
reach
"As such it would be expected that both CUL4B-DDB1 and TRAF2 enhance mTORC1 dependent S6K and 4E-BP1 phosphorylation while UCH-L1 and OTUD7B enhance mTORC2 dependent AKT phosphorylation at S473.mTOR si[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28923280
sparser
"MTOR signalling can further be downregulated through a number of ubiquitin dependent mechanisms with mTOR itself being negatively regulated by both Cul1-Skp-Fbw7 E3 ligase and the DUB USP9X . The targ[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28923280
reach
"The targeting of the Cul1, Skp, and Fbw7 complex to mTOR results in the latter 's ubiquitination and degradation while the mechanism through which USP9X inhibits mTOR signalling remains ill defined."
28923280
reach
"Ubiquitin specific peptidase 9, X linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR)."
22544753