IndraLab

Statements

Curcumin inhibits FOS. 12 / 12
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"In this study, we show that curcumin decreases the TPA- induced c-Fos elevation in the nuclear extracts in spite of the slight super-induction of c-fos mRNA."
7553596
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"Most interestingly, curcumin can reverse the expression dynamics of c-fos and fra-1 in this tumorigenic cell line, mimicking the expression pattern observed in normal controls or precancerous lesions."
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"Curcumin at 20/^ M inhibited nearly all the TEA induction of c-Fos elevation."
7553596
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"These results are similar to those of kaempferol and curcumin, which can inhibit osteoclastogenesis via downregulation of MAPKs, c-Fos, and NFATc1( Lee et al., 2014 ; Shang et al., 2016 )."
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"Curcumin inhibits the activation of NF-κB and the expression of oncogenes including c- jun , c- fos , c- myc , NIK, MAPKs, ERK, ELK, PI3K, Akt, and CDKs."
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"In addition, curcumin prevents activation of cFos through ERK (extracellular-signal-regulated kinase) and JNK [28] ."
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"Curcumin could attenuate the activation of p-ERK, p-CREB, c-fos in dorsal root ganglion to ameliorate the CCI-induced neuropathic pain."
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"Curcumin also inhibits c-Fos transcription factor activation by inhibition of extracellular-signal-regulated kinase (ERK) and JNK [49] ."
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"Furthermore, curcumin significantly inhibited c-fos."
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"Moreover, curcumin inhibits MAPK, c-Fos as well as nitric oxide synthase (NOS) activity."
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"Curcumin has also been reported to impede the expression of mRNA of c-FOS, c-JUN, c-MYC, and iNOS , the Wnt target genes in various cancer cells ( Teiten et al., 2012 )."
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"XREF_FIG shows that curcumin selectively inhibits the transcriptional activity of c-Jun and c-Fos but not c-Jun and Fra -1 in the absence of exogenous Zac1 (XREF_FIG; closed bars)."
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