IndraLab

Statements

USP8 increases the amount of ESR. 4 / 4
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"Compared with the shControl group, USP8 depletion markedly downregulated the expression of ERα protein and its target genes (PS2, GREB1, CCND1, and IL-20) (Figures 5(a)–5(d))."
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"USP8 knockdown downregulated ERα protein levels and downstream target gene expression in both E2 and ethanol groups (Figures 5(e) and 5(f))."
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"USP8 knockdown significantly reduced the level of ERα protein, which could be reverted by the proteasome inhibitor MG132 (Figure 5(g))."
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"We further hypothesized that the cell cycle-related proteins CDK2/4/6 and cyclin D1 were reduced in the shUSP8 group.We next observed that the depletion of USP8 decreased ERα protein levels."
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