IndraLab

Statements

USP12 activates TCR. 4 / 4
| 4
reach
"For instance, CYLD, USP8, USP15, USP18, USP34 and A20 negatively regulate TCR signaling, whereas USP9X, USP12, USP22, USP2a and Otud7b positively modulate TCR signaling."
31078284
reach
"After stimulating the TCR with an anti-CD3 antibody, phosphorylation of the USP12 cytoplasmic pool could be induced, allowing USP12 to translocate from the nucleus to the cytoplasm and acted directly on the substrate proteins LAT and Trat1 to stabilize the TCR complex on the T cell surface during signaling."
37752518
reach
"It has been also shown that USP12 deubiquitylated and prevented lysosomal degradation of T-cell receptor complex (TCR) to sustain TCR mediated signaling [ 20 ]."
35032679
reach
"In contrast, USP12 has been found to stabilize the TCR complex and promote TCR signaling through deubiquitylating TCR adaptor proteins LAT and Trat1 in primary mouse T lymphocytes."
33643919