IndraLab

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Selenite(2-) activates CYLD. 3 / 3
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"We found that selenite triggered cIAP degradation, and CYLD upregulation via the transcription factor lymphoid enhancer factor-1 (LEF1)."
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"These data prompted us to investigate the role of LEF1 in selenite triggered CYLD upregulation."
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"Collectively, our findings demonstrate that selenite caused CYLD upregulation via LEF1 and cIAP downregulation, both of which contribute to the degradation of ubiquitin chains on RIP1 and subsequent caspase-8 activation and apoptosis."
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