IndraLab

Statements

Vorinostat inhibits RELA. 3 / 6
3 | 3
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"Furthermore, SAHA inhibited the NF-kappaB-dependent reporter gene expression activated by TNF, TNFR1, TRADD, TRAF2, NF-kappaB-inducing kinase, IkappaBalpha kinase, and the p65 subunit of NF-kappaB."
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"It was also found that SAHA inhibits ZD55-TRAIL-induced upregulation of IκBα, p50, and p65, which are crucial molecules in the NF-κB pathway that regulates cellular growth and proliferation [38,39,40]."
37508503
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"At the molecular level, it was found that upregulation of IkappaBalpha and the p50 and p65 subunits of nuclear factor-kappaB induced by ZD55-TRAIL, can be abrogated by SAHA treatment."
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