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USP15 inhibits NEDD4. 2 / 3

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"In this study, we identified USP15 as a novel deubiquitination enzyme for IRS-2, and found that USP15 antagonizes the effect of Nedd4 on IRS-2, thereby attenuating IGF-I signaling.An anti-IRS-2 antibo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Nedd4 overexpression enhanced IRS-2 tyrosine phosphorylation as reported [16] , whereas USP15 co-expression suppressed the effects of Nedd4 ( Fig. 3 a and b)."

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USP15 inhibits NEDD4. 2 / 3

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