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USP2 inhibits muscle atrophy. 2 / 2

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"Taken together, these results revealed a previously unrecognized yet critical role of USP2 in the regulation of PPAR-γ signaling and in the pathogenesis of muscle atrophy.Our mechanistic investigations revealed that USP2 prevents muscle atrophy by regulating the stability of PPAR-γ, a key TF implicated in muscle metabolism and insulin sensitivity (31–33)."

39874418

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reach

"The global deletion of USP2 aggravated diabetes- and DEX-induced muscle atrophy and insulin resistance in mice."

39874418

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IndraLab

Statements

USP2 inhibits muscle atrophy. 2 / 2

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