IndraLab

Statements

Ubiquitin binds USP47. 5 / 5
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sparser
"The structural changes upon Ub-binding to USP47 are similar to those identified for USP7 xref , xref (Fig.  xref and Supplementary Fig.  xref ), although the changes in the Fingers and BL2 of USP7 are less in magnitude (1.2 and 1.8 Å, respectively)."
37740002
sparser
"The intrinsic flexibility of these loops and the Fingers region is attributed to the interaction between USP47 and ubiquitin."
37740002
sparser
"We employed this assay to conduct a targeted RNAi screen using a focused dsRNA library encompassing factors linked to ubiquitin-proteasome function ( xref ; xref ) that might interact genetically with Usp47 ."
27552662
reach
"Together, Ub binding appears to induce considerable conformational changes in the SL, BL1, BL2, and Fingers, which positions the Ub and realigns the catalytic residues into place for catalysis.The structural changes upon Ub-binding to USP47 are similar to those identified for USP7 (Fig. 3f and Supplementary Fig. 8), although the changes in the Fingers and BL2 of USP7 are less in magnitude (1.2 and 1."
37740002
sparser
"The two c USP47 CD C97S :Ub complexes in an asymmetric unit had an RMSD of 0.54 Å for 354 Cα atoms."
37740002