IndraLab

Statements

Integrins activates KCNH2. 7 / 7
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"In particular, we studied if pH regulating mechanisms provide a direct link between integrin-mediated hERG1-dependent cell adhesion and the tumor microenvironment."
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"We first studied how integrin engagement stimulates hERG1 current (I ) in HEK 293 cells stably expressing hERG1 (HEK–hERG1 cells) seeded on FN-coated dishes, which activates β1 integrins (Arcangeli et al, 1993; Hofmann et al, 2001)."
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"Indeed, integrin blockade inhibited signaling down-stream of hERG1 [167] ."
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"The Interaction between hERG1 and β1 Integrins Modulates hERG1 Current in Different Pathological Cell Models."
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"Based on such evidence, we propose a working hypothesis of how hERG1 regulates the sequence of cellular events triggered by integrin-dependent cell adhesion ( Figure 2 , Key Figure), for comparison wi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The link between hERG1 and integrins is twofold : integrins, mainly the beta1 integrin subunit, can activate hERG1."
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"Cell adhesion via integrin β 1 causes activation of hERG1, which is essential for direct FAK phosphorylation ( xref ). xref "
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